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Large-system transformation in healthcare: a realist review

Best, A. et al. The Millbank Quarterly, 2012; 90 (3): 421-456

Realist review methodology can be applied in combination with a complex system lens on published literature to produce a knowledge synthesis
that informs a prospective change effort in large-system transformation.
A collaborative process engaging both research producers and research users
contributes to local applications of universal principles and mid-range theories,
as well as to a more robust knowledge base for applied research. We conclude
with suggestions for the future development of synthesis and evaluation
methods.

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