A Cochrane review has found insufficient evidence that antidepressants can be safely used for chronic pain management. The review found that although Duloxetine was consistently the highest‐ranked antidepressant with moderate‐ to high‐certainty evidence, there is currently no reliable evidence for the long‐term efficacy of any antidepressant, and no reliable evidence for the safety of antidepressants for chronic pain at any time point.